4-Bromophenylboronic Acid CAS 5467-74-3: Properties, Uses, and Supplier Selection Guide

4-Bromophenylboronic acid, CAS 5467-74-3, is an aromatic boronic acid used primarily as a bifunctional building block in organic synthesis. Its molecular formula is C₆H₆BBrO₂, and its commonly reported molecular weight is approximately 200.83 g/mol. The molecule combines a boronic acid group for cross-coupling chemistry with a para-bromo substituent that can support further functionalization. I recommend selecting this material by confirmed identity, assay, impurity profile, packaging, and supply reliability rather than by price alone.

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Who This Guide Is For

This guide is intended for procurement teams, process chemists, medicinal chemistry groups, custom synthesis companies, and manufacturers evaluating 4-Bromophenylboronic acid for laboratory or production use. It is also useful when comparing suppliers for a development project that may move from gram-scale screening to larger batch requirements. Because actual requirements differ by reaction and application, I recommend confirming the intended scale, analytical method, and delivery schedule before placing an order.

What 4-Bromophenylboronic Acid Is

4-Bromophenylboronic acid is an organoboron compound in which a boronic acid group is attached to a phenyl ring containing bromine at the para position. The boronic acid functionality commonly participates in palladium-catalyzed Suzuki–Miyaura coupling with suitable aryl or vinyl halides. The bromine substituent may also provide a second point for subsequent chemical transformation, depending on the reaction sequence.

Types, Material Options, and Specification Considerations

For most buyers, the principal material choice is not a different chemical structure but a different specification level and packaging format. Research-use material may be purchased in small containers, while process-development or manufacturing programs may require larger packs, lot consistency, and documented analytical control. I recommend requesting the exact assay method, water content where relevant, residual solvent information, and impurity limits before comparing quotations.

Purity and Analytical Documentation

Assay is an important starting point, but it does not describe every attribute that can affect a coupling reaction. A buyer may also need HPLC or GC data, NMR confirmation, water content, residue on ignition, and an identification result appropriate to the material. Maison Chemical can discuss the required specification and provide available batch documentation, such as a Certificate of Analysis, subject to the product grade and order scope.

Packaging and Handling Format

Packaging should protect the solid from moisture, contamination, and unnecessary exposure during repeated use. The appropriate container size depends on whether the material will be consumed quickly or opened repeatedly over an extended project. I suggest asking for pack sizes, labeling details, storage guidance, and whether the outer packaging is suitable for international shipment.

Where 4-Bromophenylboronic Acid Is Used

The most established use is as a reagent or intermediate for carbon–carbon bond formation, especially Suzuki–Miyaura coupling. In this role, the boronic acid group is converted into a new aryl bond under suitable catalyst, base, solvent, and temperature conditions. The exact reaction performance depends on the partner substrate and process conditions, so the compound should be evaluated using the buyer’s own validated procedure.

Its second major value is synthetic flexibility. The aryl bromide can remain available for later transformations, allowing chemists to design sequential or convergent routes. This feature makes the compound relevant to pharmaceutical intermediates, agrochemical research, specialty materials, and other discovery or process chemistry programs where controlled substitution patterns are important.

Application Matching

• Medicinal chemistry: useful for preparing substituted biaryl or heteroaryl analogues during structure–activity relationship work.
• Process development: suitable for route evaluation when impurity control, reproducibility, and scalable supply are important.
• Custom synthesis: relevant as a starting material for multi-step intermediates with defined aromatic substitution.
• Materials research: potentially useful in the synthesis of functional aromatic structures, subject to route-specific compatibility.

How to Select a Supplier

I recommend using a structured selection framework rather than choosing the lowest quoted unit price. First, confirm that the supplier is offering 4-Bromophenylboronic acid with CAS 5467-74-3, not a positional isomer or a similarly named bromophenyl compound. Next, compare analytical specifications, batch documentation, packaging, lead time, export capability, and communication quality.

Step 1: Define the Technical Requirement

State the intended use, target quantity, required assay, acceptable impurity profile, and preferred delivery location. If the material will enter a regulated or controlled development process, identify documentation requirements at the beginning. Clear specifications reduce the risk of receiving a product that is chemically correct but unsuitable for the intended procedure.

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Step 2: Request Evidence for the Offered Lot

Ask for a current or representative CoA, product specification, SDS, and available analytical data. The documentation should identify the product, lot or batch information where applicable, test methods, and release results. I advise buyers to distinguish between a representative specification and actual lot-specific results.

Step 3: Evaluate Supply and Logistics

Compare available pack sizes, minimum order quantity, production or preparation lead time, shipment terms, and export documentation. A small difference in price may be less important than a missed development milestone or an inconsistent second batch. For international orders, confirm the destination requirements, labeling, customs information, and transport conditions before shipment.

Step 4: Check Scale-Up Support

If the project may increase from laboratory quantities to larger requirements, ask whether the supplier can discuss a repeat-order plan. Useful questions include whether the same specification can be maintained, how batch changes are communicated, and what support is available for technical clarification. Maison Chemical supports B2B buyers by discussing specifications, packaging, documentation, and quotation requirements for 4-Bromophenylboronic acid.

Pricing, MOQ, and Lead-Time Factors

The price of 4-Bromophenylboronic acid can vary with purity, order quantity, packaging, testing requirements, production status, and shipping destination. I do not recommend treating a single online price as a reliable benchmark because a quotation may exclude testing, special packaging, freight, or export-related charges. A written request for quotation should include the desired quantity, grade, destination, and documentation requirements.

Minimum order quantity is also supplier-specific. Some suppliers may offer laboratory packs, while others focus on larger commercial quantities or made-to-order production. Lead time may depend on current inventory and whether additional quality testing or customized packaging is required, so buyers should request a confirmed schedule rather than relying on a general catalog statement.

Common Buyer Mistakes

One common mistake is ordering by name alone without confirming the CAS number and molecular formula. Another is comparing assay percentages while ignoring moisture, residual solvents, inorganic residues, or unidentified peaks that may affect a sensitive reaction. Buyers should also avoid assuming that a small laboratory pack and a larger production batch will have identical documentation or release procedures without written confirmation.

Storage and handling should follow the supplier’s SDS and the buyer’s internal chemical management procedures. Boronic acids can be sensitive to conditions such as moisture and prolonged exposure to unsuitable environments, although the appropriate controls depend on the specific packaging and formulation. Before use, inspect the container, label, appearance, and documentation, and contact the supplier if any discrepancy is observed.

Supplier Evaluation Checklist

• Correct identity: 4-Bromophenylboronic acid, CAS 5467-74-3.
• Confirmed formula and molecular weight: C₆H₆BBrO₂ and approximately 200.83 g/mol.
• Defined assay and impurity specifications.
• Available CoA, SDS, and suitable analytical support.
• Transparent MOQ, pack size, lead time, and quotation validity.
• Ability to discuss repeat supply and project-scale requirements.
• Appropriate export, labeling, and shipment documentation.

Key Takeaways

4-Bromophenylboronic acid CAS 5467-74-3 is a versatile aromatic building block with both a boronic acid group and a para-bromo substituent. Its approximately 200.83 g/mol molecular weight and dual functional character make it relevant to cross-coupling and multi-step synthesis, but final suitability must be confirmed through application-specific testing. The strongest supplier decision combines chemical identity, documented quality, logistics, and long-term supply support.

Conclusion: Choosing a Reliable Supply Route

If you need 4-Bromophenylboronic acid for research, intermediate synthesis, or process development, begin by defining the required specification and quantity, then request lot documentation and a complete commercial quotation. I recommend comparing suppliers on verified quality data, communication, packaging, lead time, and the ability to support repeat orders—not only on unit cost. Maison Chemical is available to discuss 4-Bromophenylboronic acid CAS 5467-74-3, including product specifications, pack sizes, documentation, and B2B quotation requirements.

For a quotation or technical discussion, please provide your target quantity, required purity, destination, packaging preference, and documentation needs.

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