1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic Acid Pinacol Ester CAS 903550-26-5: A Buyer’s Guide to Uses, Specifications, and Sourcing

I use 1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester, CAS 903550-26-5, as the purchasing name for a protected pyrazole boronic ester used primarily as a research and synthesis intermediate. Its main value is the combination of a pyrazole ring, a boronic acid pinacol ester coupling handle, and a tetrahydropyranyl protecting group. For buyers, the most important checks are identity confirmation, assay and impurity data, physical form, packaging, storage conditions, and whether the supplier can support repeat or project-based delivery.

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At Maison Chemical, I recommend evaluating this material against the exact reaction route rather than selecting it from the CAS number alone. The same substance can be suitable for medicinal chemistry, pharmaceutical intermediate development, or custom synthesis, but the required documentation and batch scale may differ considerably. I also advise buyers to request a current specification sheet and certificate of analysis before placing a commercial order.

Who This Guide Is For

This guide is intended for procurement teams, process chemists, medicinal chemistry groups, contract research organizations, and manufacturers sourcing CAS 903550-26-5. It is also useful for buyers comparing catalog supply with a specialized chemical manufacturer or exporter. I focus on practical sourcing questions, including how to match grade, quantity, documentation, and delivery expectations to the intended application.

The compound should generally be treated as a specialty organic intermediate rather than as a finished pharmaceutical ingredient. Its suitability for a specific synthesis depends on the reaction conditions, downstream purification process, impurity tolerance, and internal quality requirements. Buyers should therefore share the intended use and technical expectations with the supplier as early as possible.

Basic Chemical Context

1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester contains three functionally important elements. The pyrazole ring provides a nitrogen-containing heteroaromatic scaffold, the boronic acid pinacol ester provides a protected boron functionality commonly used in carbon–carbon bond-forming chemistry, and the tetrahydropyranyl group protects the pyrazole nitrogen during selected synthetic sequences.

The boronic ester is often selected for cross-coupling development because it can participate in reactions that connect the pyrazole fragment with an aryl, heteroaryl, or other compatible electrophilic partner. The tetrahydropyranyl group may be removed or retained depending on the route design. Actual performance is reaction-specific, so I do not recommend treating the compound as universally interchangeable with an unprotected pyrazole or another boronic ester.

Identity and Reference Information

Formula and molecular-weight listings should be checked against the current batch documentation because commercial databases and supplier records can occasionally differ in formatting or transcription. I consider the CAS number an important starting point, but not a substitute for analytical confirmation. A buyer should compare the supplier’s name, structure, formula, molecular weight, and analytical data before approving the material.

Types, Grades, and Specification Options

For this product, “type” usually refers less to a different chemical form and more to the supply specification, packaging size, and documentation package. A research quantity may be appropriate for route screening, while a development or production-support quantity may require tighter controls over assay, residual solvents, water content, and trace impurities. I recommend asking whether the quoted material is a standard stock item, a freshly prepared batch, or a custom production lot.

Typical Specification Categories

• Identity: CAS number, chemical name, structure, and analytical confirmation such as NMR, LC-MS, or other applicable methods.
• Assay or purity: The reported value and analytical method should be stated clearly rather than represented only by a broad “high purity” description.
• Related substances: Relevant for route development and downstream purification, especially when the material enters a multi-step synthesis.
• Water and residual solvents: Important because boronic esters and moisture-sensitive reaction systems may respond to storage and handling conditions.
• Physical form: Buyers should confirm whether the supplied material is a solid or powder and whether color variation is controlled within the agreed specification.
• Packaging and storage: The supplier should state the recommended container, protection from moisture or light where applicable, and transport precautions.

I avoid assigning a universal purity value when the batch specification has not been provided. For example, one project may accept a research-grade material for exploratory chemistry, while another may require a customer-approved limit for individual impurities. The correct specification is the one that supports the buyer’s validated or planned process.

Matching the Product to the Application

CAS 903550-26-5 is most relevant when a synthesis requires a protected pyrazole fragment bearing a boronic ester functionality. In medicinal chemistry, it may support the preparation of analog libraries or focused compound series. In pharmaceutical intermediate development, it may be evaluated as one step in a longer route, subject to process robustness, impurity control, and scale-up assessment.

It may also be useful in custom synthesis and early-stage route scouting where chemists compare several heteroaryl building blocks. However, buyers should not assume that the compound is suitable for every coupling system. Catalyst selection, base, solvent, temperature, reaction time, substrate compatibility, and work-up conditions all influence the practical result.

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Application-Matching Questions

1. Is the tetrahydropyranyl-protected pyrazole required for chemoselectivity or route control?
2. Will the boronic ester be used in a coupling step, or is the compound intended for another transformation?
3. What assay, impurity, water, and residual-solvent limits are needed for the next step?
4. Is the initial requirement a small screening quantity, a development batch, or repeated commercial supply?
5. Does the project require specific analytical files, custom labeling, or export documentation?

A Practical Buyer Selection Framework

I suggest using a four-stage selection framework: identity, quality, supply capability, and commercial fit. First, verify that the supplier’s structure and CAS number match the requested compound. Second, review the available analytical package and determine whether the stated tests are relevant to the intended route.

Third, assess whether the supplier can provide the required quantity and repeatability. A supplier who can offer only a one-time sample may not be suitable for a project that could move from milligram-scale screening to kilogram-scale process development. Finally, compare the total sourcing risk, including packaging, transit time, import requirements, payment terms, and communication quality rather than comparing price alone.

Pricing, MOQ, and Lead-Time Considerations

The price of a specialty intermediate such as CAS 903550-26-5 can vary with quantity, purity target, analytical requirements, packaging, and whether the material is available from stock. I do not recommend publishing a single fixed price without confirming these variables. A small research pack, a development batch, and a repeat manufacturing order should normally be evaluated as different purchasing cases.

MOQ and lead time should be confirmed in writing at the quotation stage. For planning purposes, buyers should ask for both the earliest dispatch date and the expected production schedule if the material is not currently stocked. I also recommend confirming whether the quoted lead time includes quality release, export documentation, and transportation or refers only to manufacturing completion.

Common Sourcing Mistakes

One common mistake is ordering by name alone without reviewing the structure and CAS number. Another is accepting a purity statement without asking which analytical method was used or whether related substances are reported separately. Buyers can also create avoidable delays by requesting shipping after the order is placed instead of discussing packaging, labeling, and destination requirements in advance.

A further risk is purchasing too little material to evaluate both the reaction and the downstream purification. I recommend aligning the first order with the planned screening matrix and retaining enough material for confirmation experiments where practical. At the same time, buyers should avoid over-ordering before the route and storage suitability have been assessed.

How Maison Chemical Supports Sourcing

At Maison Chemical, I position our support around clear product identification, practical quotation, and communication suitable for international B2B chemical purchasing. We can review the requested CAS number, target quantity, documentation needs, packaging expectations, and destination before preparing a supply proposal. Where the project requires a specific quality profile, I recommend discussing those requirements before the order is confirmed.

Our role is not limited to offering a product name and a price. We aim to help buyers distinguish between sample procurement, route-development supply, and repeat commercial requirements. Availability, batch documentation, packaging, and lead time should be confirmed for each inquiry because these details can change with order quantity and production scheduling.

Key Takeaways

• CAS 903550-26-5 is a protected pyrazole boronic ester used as a specialty synthesis intermediate.
• Its principal purchasing advantages are the defined heteroaryl scaffold, protected nitrogen, and boronic ester coupling functionality.
• Buyers should verify identity, assay, impurity data, water or residual-solvent requirements, packaging, storage, MOQ, and lead time.
• A current specification sheet and batch certificate of analysis are more reliable than an unqualified catalog description.
• The best supplier is the one that can support the required scale, documentation, repeatability, and delivery plan.

Conclusion: How to Source CAS 903550-26-5 with Greater Confidence

The most reliable way to buy 1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester CAS 903550-26-5 is to treat the purchase as a technical sourcing decision, not simply a catalog transaction. Start by confirming the identity and intended reaction role, then define the required assay, impurity, packaging, and documentation criteria. After that, compare suppliers on supply continuity, communication, MOQ, lead time, and total project risk.

If you are evaluating this compound for medicinal chemistry, pharmaceutical intermediate development, or custom synthesis, contact Maison Chemical with the CAS number, required quantity, destination, target specification, and preferred delivery schedule. I can then help prepare a more relevant quotation and clarify the documentation or supply details needed for your project.

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