What Is 3,5-Dichlorophenylboronic Acid CAS 67492-50-6? Uses, Specifications, and Supplier Information

3,5-Dichlorophenylboronic acid CAS 67492-50-6 is a halogenated arylboronic acid used primarily as a synthetic building block in organic and medicinal chemistry. It contains a phenyl ring substituted with chlorine atoms at the 3- and 5-positions and a boronic acid group that can participate in palladium-catalyzed cross-coupling reactions, especially Suzuki–Miyaura coupling. Its commonly reported molecular formula is C₆H₅BCl₂O₂, with a calculated molecular weight of approximately 190.82 g/mol. At Maison Chemical, we support B2B buyers by helping them confirm identity, quality requirements, documentation, packaging, and supply feasibility before an order is placed.

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Identity and Core Chemical Function

3,5-Dichlorophenylboronic acid belongs to the family of organic boronic acids, which contain a carbon–boron bond and a boronic acid functional group. The boron center is chemically useful because it can undergo transmetalation during suitable cross-coupling reactions, allowing the aryl group to be transferred to another reaction partner. The two chlorine substituents modify the electronic and steric characteristics of the aromatic ring, which may influence reaction behavior and the properties of the final molecule.

The CAS number is 67492-50-6, and the chemical name identifies both the functional group and the substitution pattern. Buyers should distinguish this material from other dichlorophenylboronic acid isomers because positional isomers can have different reactivity, analytical profiles, and application suitability. Before procurement, we recommend confirming the CAS number, molecular formula, structure, and intended reaction route against the project specification.

Known Uses and Application Scenarios

Cross-Coupling and Pharmaceutical Intermediates

The most established use of arylboronic acids is as coupling partners in carbon–carbon bond-forming chemistry. In Suzuki–Miyaura reactions, an arylboronic acid may react with an aryl or vinyl halide under an appropriate catalyst and base system to produce a biaryl or related conjugated structure. The exact yield and selectivity depend on the reaction design, catalyst, solvent, base, temperature, and substrate combination, so the product should be treated as a valuable starting material rather than a guaranteed process outcome.

3,5-Dichlorophenylboronic acid can be considered when a synthetic route requires a dichlorinated aromatic fragment. Such fragments may appear in research programs involving pharmaceutical intermediates, agrochemical intermediates, specialty ligands, and other advanced organic molecules. The compound is generally more relevant to discovery, process development, and custom synthesis than to direct consumer applications.

Medicinal and Materials Chemistry

In medicinal chemistry, the compound may be used to introduce a substituted aromatic ring into a candidate molecule. The chlorine atoms can remain in the final structure or serve as part of a broader design strategy involving subsequent functionalization, depending on the route. In materials and functional-molecule research, arylboronic acids may also be evaluated as intermediates for compounds with tailored electronic or structural properties.

Because application performance depends on the complete reaction system, buyers should evaluate this material together with the intended partner substrate and process conditions. A supplier can provide identity and quality documentation, but reaction optimization normally remains the responsibility of the development team unless a separate technical service is agreed.

Types, Forms, and Material Options

For purchasing purposes, the main distinction is usually not a different “type” of 3,5-Dichlorophenylboronic acid, but the quality grade, packaging, documentation level, and batch size. Research-grade material may be suitable for early-stage screening, while process-development or commercial programs may require tighter impurity controls, larger quantities, and a documented change-control approach.

Physical appearance should be confirmed from the current specification or certificate of analysis rather than assumed from a generic database entry. Arylboronic acids are commonly handled as solid chemical intermediates, but moisture exposure, storage conditions, and packaging can affect material condition over time. We advise buyers to request the current product specification, recommended storage instructions, and safety data sheet before approving a supply source.

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Key Specifications Buyers Should Confirm

The calculated molecular weight is approximately 190.82 g/mol, which buyers can use for preliminary stoichiometric calculations. This value should not replace the supplier’s current technical documentation, particularly where hydrate, solvate, or analytical reporting issues may be relevant. If the product will be used in a regulated or highly controlled process, request a lot-specific certificate of analysis rather than relying only on a catalog description.

Handling and Storage Considerations

3,5-Dichlorophenylboronic acid should be handled according to the supplier’s safety data sheet and the customer’s internal chemical-safety procedures. Personnel should use appropriate protective equipment, avoid generating dust, and work with suitable ventilation and containment. The correct controls depend on the quantity, process, exposure route, and site risk assessment.

Storage conditions should be confirmed from the current SDS and product specification. In general, buyers should keep the material in its original, properly closed container and protect it from incompatible conditions, moisture, and unnecessary heat or light exposure where applicable. We do not recommend assuming a universal shelf life or storage temperature without batch-specific or supplier-issued guidance.

How to Select a Supplier

Quality and Documentation

A reliable supplier should be able to confirm the product identity and provide documentation appropriate to the order. At minimum, buyers commonly request a specification sheet, SDS, certificate of analysis, batch or lot identification, packaging details, and country-of-origin information when required for import or internal compliance. Additional documents should be discussed before purchase because availability can vary by product grade and destination.

Supply Capability and Commercial Fit

Supplier selection should consider more than the quoted price. Buyers should compare minimum order quantity, available batch size, production or dispatch lead time, packaging options, transport classification, and the supplier’s ability to maintain consistent specifications across repeat orders. For development work, a small evaluation quantity may be practical; for process work, continuity of supply and change notification may be more important than the initial unit price.

Maison Chemical serves B2B customers seeking organic boronic acids and related chemical intermediates. We can discuss the required quantity, purity target, packaging, destination, documentation, and intended application so that the quotation is based on a clear technical and commercial brief. Where a requirement is not fully defined, we use conservative language and recommend confirming critical parameters before order release.

Buyer Checklist Before Ordering

1. Confirm that the requested material is specifically 3,5-Dichlorophenylboronic acid with CAS 67492-50-6.
2. Check the molecular formula, stated molecular weight, structure, and required purity.
3. Define acceptable limits for water, residual solvents, related substances, and other critical impurities.
4. Request the current SDS, specification, and representative or lot-specific certificate of analysis.
5. Confirm packaging, net quantity, labeling, storage instructions, and transport requirements.
6. Compare MOQ, lead time, repeat-supply capability, and documentation support.

Summary Insights

• 3,5-Dichlorophenylboronic acid is a halogenated arylboronic acid and synthetic building block.
• Its CAS number is 67492-50-6, and its commonly reported formula is C₆H₅BCl₂O₂.
• The calculated molecular weight is approximately 190.82 g/mol.
• Its principal relevance is in cross-coupling, medicinal chemistry, and advanced intermediate synthesis.
• Quality, moisture-related controls, documentation, packaging, and supply continuity should be confirmed before purchasing.

Conclusion and Next Steps

3,5-Dichlorophenylboronic acid CAS 67492-50-6 is a specialized organic boronic acid used mainly to introduce a 3,5-dichlorophenyl fragment into synthetic molecules. Its value comes from the reactivity of the boronic acid group, while the chlorine substitution pattern provides a defined aromatic building block for research and process-development chemistry. The most suitable grade depends on your reaction route, purity requirement, analytical method, quantity, and documentation needs.

To begin a sourcing discussion with Maison Chemical, prepare the requested quantity, target purity, destination country, packaging preference, required documents, and project timing. We can then review the specification and provide a practical quotation based on current availability and commercial requirements. For regulated, scale-up, or repeat-use projects, we recommend evaluating a representative batch and agreeing on acceptance criteria before moving to larger procurement.

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