Stopper Functionality Key Considerations - Bioprocess Online

When selecting the appropriate rubber stopper for any respective vial containment system, there are many aspects to consider regarding the properties of the elastomeric closure. For the purposes of this discussion, the focus will be on the functional performance of the stopper and what key aspects should be considered during the assessment and selection process. Coring and fragmentation, container closure integrity, and machinability of the stoppers will be briefly reviewed.

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It is also important to consider for all these assessments that they are conducted under pharmaceutically representative conditions, when possible, such as ensuring components are lubricated, washed and sterilized as intended for commercial use.

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