Butyric Acid Benefits and Butyric Acid Food List - Zuma Nutrition

Butyric acid is a fatty acid created when the beneficial bacteria in your gut break down dietary fiber. It also exists in small amounts in some foods like vegetable oils and animal fats. Butyric acid has numerous benefits to gut health and can play a role in repairing the gut lining. In this article, we will explore butyric acid benefits in depth.

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What Is Butyric Acid?

When the beneficial bacteria in your gut break down dietary fiber, they produce a short-chain fatty acid called butyric acid, also known as butyrate and butanoic acid. This fatty acid is also present in some foods, like animal fats and vegetable oils.

Short-chain fatty acids are fatty acids that come from when beneficial bacteria break down dietary fiber, and butyric acid is one of the three most common short-chain fatty acids in the gut. The two most common short-chain fatty acids are propionic acid and acetic acid. Together these three fatty acids compose up to 95% of the short-chain fatty acids in your gut.

Short-chain fatty acids like butyric acid provide colon cells with energy. Short-chain fatty acids also modulate the tissue metabolism of carbohydrates and lipids. As a result, short-chain fatty acids can improve gut health, from maintaining intestinal barrier integrity and mucus production to protecting against inflammation and preventing digestive disorders and diseases.

While gut bacteria produce butyric acid, many people have disrupted gut microbiomes that can limit butyric acid production. Butyric acid is in foods in small amounts; however, the amounts are not significant enough to provide many benefits. Because of this, butyric acid supplements can be a great support to restoring gut health in numerous ways.

What Are the Benefits of Butyric Acid?

There are many butyric acid benefits. Some of the top butyric acid uses include:

Butyric Acid May Repair the Gut Lining

Your gut lining is a single-cell thick wall that allows nutrients to pass through your bloodstream while keeping toxins out. However, poor diet, gut inflammation, Candida overgrowth, and imbalances in the gut microbiome can create tiny holes in the gut lining. When this happens, toxins and undigested food particles pass through your blood. This condition is known as intestinal permeability or leaky gut syndrome. 

 When someone has leaky gut syndrome, toxins leaking into the bloodstream get distributed throughout the body. As a result, they can impact the health of major organs and tissues. The body recognizes the food particles that pass through as pathogens to the immune system. The immune system then creates antibodies that attack these food particles whenever they enter the body. This immune response leads to food allergies and sensitivities that you never had before. In fact, according to research by Harvard Medical School, leaky gut is at the root of numerous health conditions. 

 Butyric Acid is a powerful compound that fights leaky gut by helping to repair the gut lining. It produces short-chain fatty acids that restore damaged intestinal tissue. 

Butyric acid also acts on the fungal stage of candida, destroying the root-like structures that penetrate the gut lining and contribute to a leaky gut.

A leaky gut can contribute to numerous health conditions, such as:

• Chronic diarrhea, constipation, or bloating
• Nutritional deficiencies
• Tiredness and fatigue 
• Headaches 
• Brain fog and confusion
• Difficulty concentrating
• Skin problems, such as acne, rashes, or eczema
• Joint pain
• Widespread inflammation
• Chronic liver disease
• Diabetes
• Food allergies and sensitivities
• Polycystic ovary syndrome and much more.

Butyric acid can play a crucial role in healing leaky gut when used as part of a more comprehensive GI protocol.

Butyric Acid May Lower Gut Inflammation

Inflammation is a natural process of the body and is a significant function of your immune system. When your body is injured or at risk of infection from toxins or pathogens, your body has a localized inflammatory response that plays a critical role in healing.

Short-term inflammation is beneficial; however, if inflammation persists over time, it can become chronic and detrimental to your health. For example, chronic inflammation in the gut can disrupt digestive health and be harmful to the gut lining. Chronic gut inflammation is a major contributing factor to the leaky gut syndrome.

Not only can butyric acid help heal leaky gut and repair the gut lining, but it can also lower the inflammation that is a major cause of leaky gut syndrome. Of course, it is essential to focus on removing things from your diet and lifestyle that may contribute to a leaky gut in the first place. Still, butyric acid may play a beneficial role in keeping gut inflammation levels low and supporting gut healing.

Butyric Acid May Help Treat Irritable Bowel Syndrome and Crohn’s disease

Irritable bowel syndrome (IBS) is a common digestive disorder that affects the large intestine. People with irritable bowel syndrome may suffer from cramping, abdominal pain, bloating, gas, diarrhea or constipation, or both.

Chron’s disease is a chronic inflammatory bowel disease that affects the lining of the digestive tract. It can cause abdominal pain, diarrhea, weight loss, fatigue, and anemia.

Butyric Acid May Help Eliminate Candida Infections

Candida is a type of yeast that naturally lives in your body in small amounts. Typically, the good bacteria in your gut and your immune system keep Candida levels under control. However, when the balance of good bacteria to yeast is not balanced, candida can grow out of control and lead to a Candida infection.

Candida yeast is single-celled fungi. When candida can grow beyond normal levels, they take on a pathogenic fungal form that travels up the intestinal wall. This form of candida can penetrate the gut lining, leading to leaky gut syndrome.

Butyric acid helps preserve the strength and integrity of the gut lining and may contain antifungal properties that can kill the fungal stage of candida. Supplementing with butyric acid may play a beneficial role in treating Candida infections and restoring damage to the gut lining caused by candida.

Butyric Acid May Support Liver Health

Some research has also shown that butyric acid may influence inflammatory markers in the liver. However, the underlying mechanism of butyric acid’s effect on liver health is still uncertain.

What Foods Contain Butyric Acid?

While butyric acid is primarily produced in the gut by beneficial bacteria, certain foods contain butyric acid. Some of the top butyric acid foods include:

• Ghee
• Butter
• Cow milk
• Goat milk
• Red meat
• Vegetable oils
• Parmesan cheese
• Sauerkraut

Ghee and butter are the best butyric acid-rich foods as they are particularly high in short-chain fatty acids. Milk is another food rich in butyric acid. There are small amounts of butyric acid in chocolate, but only in milk chocolate, as the butyric acid exists in the milk fats. There is no butyric acid in the chocolate itself. 

In the gut, butyric acid is produced by beneficial bacteria when they break down dietary fiber. Therefore, including more dietary fiber in your diet may improve butyric acid production. In addition, supplementing with high-quality probiotics may also increase the beneficial bacteria in your gut.

Prebiotic foods contain resistant starches that your body can’t break down but relies on bacteria to break down. Foods that are high in resistant starches are the best foods to consume for increasing natural butyric acid production. Some of the best prebiotic foods include: 

• artichokes
• garlic
• onions
• potatoes
• bananas
• apples
• apricots
• carrots
• asparagus
• oat bran

Arabinogalactan is another highly beneficial prebiotic that comes from the larch tree and can help to increase natural butyric acid production.

While there are some butyric acid foods, supplementing with butyric acid can provide more amounts of butyric acid than those found in food, allowing you to receive more of the benefits of this beneficial fatty acid.

Are There Side Effects of Taking Butyric Acid?

There is no research suggesting any side effects to supplementing with butyric acid or eating butyric acid foods. However, avoid supplementing with butyric acid if you are pregnant or breastfeeding. Always consult a licensed doctor before taking dietary supplements, especially if you have pre-existing health conditions.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/

https://www.sciencedirect.com/science/article/pii/S

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/

https://pubmed.ncbi.nlm.nih.gov//

https://www.health.harvard.edu/blog/leaky-gut-what-is-it-and-what-does-it-mean-for-you-

https://scholar.harvard.edu/pushpanathan/publications/leaky-gut-syndrome-mystery-illness-triggered-candida-albicans

https://www.ncbi.nlm.nih.gov/books/NBK/

Are you looking for an all-natural supplement to provide relief from symptoms such as gas, bloating and abdominal discomfort? Well your not alone, with gut issues affecting more and more people many are trying various probiotics, prebiotics and “gut formulas”. Butyrate supplements are one of the lesser known gut health supplements that is fast becoming a more popular choice. Find out why Butyrate (sometimes known as Butyric Acid) is fast becoming the ‘go to’ supplement for Australians seeking a healthy gut and where to buy the best Butyrate supplements in Australia.

What is Butyrate & Why is it Beneficial to Gut Health?

Butyrate is an essential short-chain fatty acid (SCFA) along with acetate, propionate & valerate which is produced naturally by intestinal bacteria in the large intestine. Butyrate is often used synonymously with sodium butyrate, butyric acid & butanoic acid. Butyrate is found in certain foods such as full-fat dairy. A little bit of trivia… The name Butyrate is actually derived from butter in Greek. Comparative to direct food sources the majority of butyrate comes from the fermentation process by specific gut bacteria when they break down dietary fiber such as non-digestible carbohydrates and in the process produce short chain fatty acids including butyrate. Whilst there are many bacteria in the gut that produce butyrate, some of the common and potent butyrate-producing bacteria are faecalibacterium prausnitzii, Roseburia spp., and Eubacterium rectale.

Why is Butyrate So Important?

Within the gut, butyrate has many health benefits. It helps regulate a healthy immune system, keep inflammation at bay, assist with the replication of new cells that make up the gut lining, maintain the intestinal barrier & possibly most importantly Butyrate functions as a primary source of energy for the intestinal epithelial cells. All these key features of butyrate helps to maintain healthy gut flora in the large intestine and promote optimal digestive health.

Outside of the gut butyrate has been shown to have positive effects on sleep, diabetes & in animal studies a host of neurodegenerative disorders such as Parkinson's disease & Alzheimers are showing some promising results. I suspect very shortly we are going to see more human studies carried out looking at butyrate's potential role in the management of these diseases.

Butyrate Prevents Gut Inflammation

One the most studied effects of butyrate is the anti-inflammatory effects it has in the gut. Studies have shown butyrate inhibits the expression of certain inflammatory mediators such as iNOS, TNF-α, and IL-6, whilst promoting the anti-inflammatory cytokine IL-10. Butyrate has also been shown to activate anti-inflammatory cells such as Tregs and M2 macrophages. Butyrate influences gut macrophage differentiation to produce non-inflammatory anti-microbial macrophages. In a study where by researchers supplemented mice with butyrate they found that the macrophages in these mice had significantly enhanced anti-microbial activity

Butyrate also has antioxidant properties which is seen by it's ability to increase the activity of the antioxidant enzymes superoxide dismutase-2, catalase & glutathione which further contributes to it's anti-inflammatory effect in the gut & how it is involved with mopping up free radicals.

A feature of Inflammatory Bowel Disease (IBD) and what distinguishes it from Irritable Bowel Syndrome (IBS) is the presence of significant inflammation levels in the gut. Studies have shown that in patients with inflammatory bowel disease typically what is observed with the gut microbiome is decreased levels of SCFAs-producing bacteria in particular butyrate.

Other studies have also identified in children with IBD decreased SCFA levels in feces is a common finding comparative to healthy individuals.

In IBS it's not quite so straightforward. Whilst overall fecal SCFAs were decreased in individuals with constipation-dominant IBS compared to healthy controls, the reverse was seen with diarrhea-dominant IBS, whereby they were shown to have higher levels.

Butyrate Emerging Evidence of COVID Protection

One of the more critical roles butyrate has is it's ability to modulate our immune system via interacting with several different immune system receptors. Butyrate has been shown to promote the differentiation of important Treg immune cells, activate B lymphocytes & regulation of neutrophils.

Several studies have been done investigating the gut microbiome and it's relevance to COVID-19. For a run down on the studies and what has been shown so far check out the blog post COVID-19 : Where does the Gut Microbiome fit in?

What seems to be a common theme with the recent studies to date, the gut microbiome in people with more significant and severe symptoms of COVID-19 have dysbiosis as evidenced by increased abundance of opportunistic and pathogenic bacteria such as Enterococcus and Eneterobacteriacea coupled with a decrease of butyrate-producing bacteria such as Faecalibacterium prausnitzii compared to patients with only mild symptoms. Furthermore a reduction in butyrate producing bacteria was associated with increased levels of C Reactive Protein indicating increased inflammation.

A recent study published in found the abundance of SCFA producing bacteria was markedly reduced in symptomatic COVID-19 patients relative to healthy individuals as well as asymptomatic positive COVID-19 individuals.

It has also be shown that these alterations of decreased abundance of butyrate-producing bacterial in the gut microbiome of COVID-19 individuals persist beyond 30 days after recovery from COVID-19 and positively correlated with disease severity.

For more isobutyric acid manufacturerinformation, please contact us. We will provide professional answers.

Given these consistent findings relating the gut microbiome & COVID-19 from the studies done certain researchers have concluded:

we hypothesize that butyrate, a short-chain fatty acid initially produced by the gut microbiota, could be administered as supportive therapy to prevent immune system activation and disease progression.

Butyrates Sleep Enhancing Properties

In years gone by if someone were to say that our gut bacteria released certain chemicals & substances that impacted our sleep you'd probably think they were crazy. Turns out that bacteria do release a sleep inducing substance called Factor S & has been shown to build up in our brain when we are sleep deprived. Whilst many gaps in the research still need to be filled regarding the gut microbiome and its relationship with sleep we do know from the current studies that gut bacteria are a source of sleep-inducing signals.

In a recent study looking at the gut microbiome of patients with insomnia and comparing it to healthy controls found distinct differences in the gut microbiota in individuals with insomnia.

In this study, we observed a remarkable change in the composition of gut microbiota in patients with insomnia disorder compared with healthy controls.

Researchers have turned to short-chain fatty acids in particular butyrate to see if some of the sleep changes seen in previous studies could be due to bacterial production of butyrate. One particular study using mice the researchers mimicked the production of butyrate in the gut by orally administering tributyrin. They found a 50% increase in non-rapid-eye movement sleep (NREMS) in mice for 4 hours after the treatment, supporting their hypothesis that butyrate may serve as a sleep inducing and enhancing signaling molecule.

In another study, researches wanted to see the effect of a butyrate supplement on cognitive impairment associated with induced sleep deprivation. They gave sleep deprived mice butyrate and found it restored healthy inflammatory responses and memory impairment.

How To Optimise Butyrate In Your Gut?

Now that we have covered what butyrate is & its importance to our health let's take a closer look at how we can test for butyrate levels in the gut, how to improve our butyrate levels. Which prebiotics and what foods produce butyrate in the gut. The evidence for butyrate supplements & how to choose the best Butyrate & Butyric acid supplements.

Human cells don't produce significant amounts of butyrate and as such we are reliant on butyrate from foods such as full-fat dairy products being one of the food groups containing the most butyrate. Aside from full fat dairy there aren't any other foods that would be considered significant contributors to exogenous butyrate. Comparatively to the butyrate production from the good gut bacteria, food sources of butyrate don't stack up nearly as well. You'd have to eat considerably more butter than what would be considered healthy so not something we can solely rely on to increase butyrate levels in the gut. Therefore humans are reliant upon endogenous production within the gut for the most part.

How To Test Your Butyrate Levels

Before we move onto ways to increase butyrate levels in the gut you may be asking yourself, or I would hope that you would be at least wondering if you have low butyrate levels. Since we now have an appreciation for the importance of healthy butyrate levels in the gut, what is the best way of knowing what your butyrate level actually is? Fecal testing is a relatively straight forward way of testing for SCFAs and Butyrate levels in the gut. It is often part of a comprehensive GI microbiome mapping test such as the Complete Microbiome Mapping Stool Test in Australia. This is by far the most utilised gut testing I do with my patients and provides a comprehensive analysis of the microbiome, butyrate levels, inflammation in the gut + a few more key gut health markers. A word of caution however whilst stool testing gives us a butyrate level in the fecal sample it isn’t necessarily an accurate representation of the luminal concentration which is what is important, so personally I tend to let the clinical case and gut microbiota profile guide me in determining if we are going to supplement with butyrate.

Butyrate & Butyric Acid supplements - What are the Benefits of Taking Butyrate Supplements & What Dosage ?

Butyrate supplements can provide several advantages to those looking to improve their digestion and overall gut health. Butyrate supplementation helps support the lining of your digestive tract by maintaining intestinal pH balance, increasing energy levels, promoting healthy bacteria growth in your microbiota and aiding in nutrient absorption. Additionally, butyrate has been known to support immunity, healthy digestion and metabolism, reduce inflammation, and promote better sleep quality.

Research into the use of Butyrate as a supplement has shown promising outcomes across a range of health conditions. In one particular study, 66 participants with medically diagnosed irritable bowel syndrome were given a microencapsulated sodium butyrate supplement or placebo for 4 weeks. Pain associated with bowel movements were significantly less in the individuals who were supplementing with butyrate. There was also improvements with bowel habits and urgency in the butyrate supplement group, with the authors concluding:

It [butyrate supplement] significantly decreases the frequency of clinical symptoms including spontaneous abdominal pain, postprandial abdominal pain, abdominal pain during defecation, stool consistency and constipation.

A small clinical study of 13 patients with Crohn's Disease, which is a form of Irritable Bowel Disease investigated the effect of 4 g/day of a butyrate supplement as enteric-coated tablets for 8 weeks. 69% of patients responded favourably to the butyrate supplement and 53% achieved remission.

As for Butyrate dosage, it’s not uncommon to see dosages in the vicinity of 3-4grams used in clinical research studies & thus dosages in that ballpark are often recommended on labels of butyrate supplements.

How to select the right butyrate supplement?

When choosing a Butyrate supplement, it is important to make sure that you select one that is of the highest quality and potency in order to achieve the health benefits. Look for supplements that are free from artificial ingredients, as this ensures maximum efficacy.

Tesseract ProButyrate is a brilliant butyrate supplement offering a good therapeutic dosage as well as pioneering the field of natural supplements with their advanced absorption & delivery technology. ProButyrate® is a Butyrate supplement using the purest possible Butanoic acid, unlike other Butyric supplements that use Butyric salt. Tesseract utilises an advanced delivery system that encapsulates its supplements so that the ingredients can weather exposure to stomach acids, preventing loss of bioavailability as the result of digestion. ProButyrate is specifically designed to deliver butyrate to the colon (without the issue of dissolution in the oral cavity), making it more effective than traditional butyrate salts. It also requires a significantly lower dose to achieve therapeutic effects - only 600- mg/day compared to the traditional 3-4 g/day required with most butyrate salt formulations.

From my own clinical experience using Butyrate supplements with patients I have noticed Tesseract ProButyrate® consistently produces the most positive outcomes & a very good track record for improving constipation.

BodyBio Calcium/Magnesium Butyrate is another one that I use a lot of in clinical practice & also consistent results have been observed. BodyBio offers a good clean therapeutic dosage & reputable company that specialise in advanced supplements. BodyBio also have a straight Sodium Butyrate Supplement, which is much the same as their Calcium/Magnesium Butyrate version - the difference between the two formulas is the minerals used to bind the butyric acid, ie. Sodium vs Calcium & Magnesium which act as a buffer to allow the butyric acid to reach the gut. All in all the Butyrate concentration is identical. So which Butyrate Supplement is better between the two formulas? We stock and use the Calcium/Magnesium Butyrate formula simply to avoid adding any additional sodium to ones daily intake.

BodyBio also produce TUDCA which is another supplement I have found very beneficial with a lot of patients with many different health benefits, you can read more about TUDCA specifically over at this article.

References

Banasiewicz, T. et al. () “Microencapsulated sodium butyrate reduces the frequency of abdominal pain in patients with irritable bowel syndrome,” Colorectal Disease, 15(2), pp. 204–209. Available at: https://doi.org/10./j.-...x.

Chen, J. and Vitetta, L. () “The role of butyrate in attenuating pathobiont-induced hyperinflammation,” Immune Network, 20(2). Available at: https://doi.org/10./in..20.e15.

Chen, Z. et al. () “Association of insulin resistance and type 2 diabetes with gut microbial diversity,” JAMA Network Open, 4(7). Available at: https://doi.org/10./jamanetworkopen...

Couto, M.R. et al. () “Microbiota-derived butyrate regulates intestinal inflammation: Focus on inflammatory bowel disease,” Pharmacological Research, 159, p. . Available at: https://doi.org/10./j.phrs...

Dalile, B. et al. () “The role of short-chain fatty acids in microbiota–gut–brain communication,” Nature Reviews Gastroenterology & Hepatology, 16(8), pp. 461–478. Available at: https://doi.org/10./s-019--3.

Encarnação, J.C. et al. () “Revisit dietary fiber on colorectal cancer: Butyrate and its role on prevention and treatment,” Cancer and Metastasis Reviews, 34(3), pp. 465–478. Available at: https://doi.org/10./s-015--9.

Gao, Z. et al. () “Butyrate improves insulin sensitivity and increases energy expenditure in mice,” Diabetes, 58(7), pp. –. Available at: https://doi.org/10./db08-.

Guilloteau, P. et al. () “From the gut to the peripheral tissues: The multiple effects of Butyrate,” Nutrition Research Reviews, 23(2), pp. 366–384. Available at: https://doi.org/10./s.

Hague, A. et al. () “Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: Implications for the possible role of dietary fibre in the prevention of large-bowel cancer,” International Journal of Cancer, 55(3), pp. 498–505. Available at: https://doi.org/10./ijc..

Hernández-Flores, T.de et al. () “Role of micronutrients and gut microbiota-derived metabolites in COVID-19 recovery,” International Journal of Molecular Sciences, 23(20), p. . Available at: https://doi.org/10./ijms.

Jardou, M. and Lawson, R. () “Supportive therapy during COVID-19: The proposed mechanism of short-chain fatty acids to prevent cytokine storm and multi-organ failure,” Medical Hypotheses, 154, p. . Available at: https://doi.org/10./j.mehy...

Kim, J., Park, H., Im, J. Y., Choi, W. S. & Kim, H. S. Sodium butyrate regulates androgen receptor expression and cell cycle arrest in human prostate cancer cells. Anticancer Res. 27, – ().

Lin, H.V. et al. () “Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms,” PLoS ONE, 7(4). Available at: https://doi.org/10./journal.pone..

Lin, R. et al. () “Distinct gut microbiota and health outcomes in asymptomatic infection, viral nucleic acid test re‐positive, and Convalescent Covid‐19 cases,” mLife, 1(2), pp. 183–197. Available at: https://doi.org/10./mlf2..

M, M. & R, K. Bcl-2 expression regulates sodium butyrate-induced apoptosis in human MCF-7 breast cancer cells. Cell Growth Differ. Mol. Biol. J. Am. Assoc. Cancer Res. 7, 311–318 ().

Moens, F. and De Vuyst, L. () “Inulin-type Fructan degradation capacity ofclostridiumcluster IV and xiva butyrate-producing colon bacteria and their associated metabolic outcomes,” Beneficial Microbes, 8(3), pp. 473–490. Available at: https://doi.org/10./bm..

Nastasi, C. et al. () “The effect of short-chain fatty acids on human monocyte-derived dendritic cells,” Scientific Reports, 5(1). Available at: https://doi.org/10./srep.

Park, J.-S. et al. () “Anti-inflammatory effects of short chain fatty acids in IFN-γ-stimulated raw 264.7 murine macrophage cells: Involvement of NF-ΚB and ERK signaling pathways,” International Immunopharmacology, 7(1), pp. 70–77. Available at: https://doi.org/10./j.intimp..08.015.

Peng, L. et al. () “Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers,” The Journal of Nutrition, 139(9), pp. –. Available at: https://doi.org/10./jn.109..

SABATINO, A.D.I. et al. () “Oral butyrate for mildly to moderately active crohn's disease,” Alimentary Pharmacology and Therapeutics, 22(9), pp. 789–794. Available at: https://doi.org/10./j.-...x.

Schulthess, J. et al. () “The short chain Fatty Acid Butyrate imprints an antimicrobial program in macrophages,” Immunity, 50(2). Available at: https://doi.org/10./j.immuni..12.018.

Sun, Q. et al. () “Alterations in fecal short-chain fatty acids in patients with irritable bowel syndrome,” Medicine, 98(7). Available at: https://doi.org/10./md..

Szentirmai, É. et al. () “Butyrate, a metabolite of intestinal bacteria, enhances sleep,” Scientific Reports, 9(1). Available at: https://doi.org/10./s-019--1.

Tang, L. et al. () “Clinical significance of the correlation between changes in the major intestinal bacteria species and COVID-19 severity,” Engineering, 6(10), pp. –. Available at: https://doi.org/10./j.eng..05.013.

Tizabi, Y., Getachew, B. and Aschner, M. () “Novel pharmacotherapies in parkinson’s disease,” Neurotoxicity Research, 39(4), pp. –. Available at: https://doi.org/10./s-021--5.

Treem, W.R. et al. () “Fecal short-chain fatty acids in children with inflammatory bowel disease,” Journal of Pediatric Gastroenterology and Nutrition, 18(2), pp. 159–164. Available at: https://doi.org/10./--.

Unger, M.M. et al. () “Short chain fatty acids and gut microbiota differ between patients with parkinson's disease and age-matched controls,” Parkinsonism & Related Disorders, 32, pp. 66–72. Available at: https://doi.org/10./j.parkreldis..08.019.

van de Wouw, M. et al. () “Microbiota-gut-brain axis: Modulator of host metabolism and appetite,” The Journal of Nutrition, 147(5), pp. 727–745. Available at: https://doi.org/10./jn.116..

Vernia, F. et al. () “Dietary factors modulating colorectal carcinogenesis,” Nutrients, 13(1), p. 143. Available at: https://doi.org/10./nu.

Wang, X. et al. () “Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation,” Microbiome, 11(1). Available at: https://doi.org/10./s-022--3.

Zhang, F. et al. () “Prolonged impairment of short-chain fatty acid and L-isoleucine biosynthesis in gut microbiome in patients with covid-19,” Gastroenterology, 162(2). Available at: https://doi.org/10./j.gastro..10.013.

Zhou, J. et al. () “Alterations in gut microbiota are correlated with serum metabolites in patients with insomnia disorder,” Frontiers in Cellular and Infection Microbiology, 12. Available at: https://doi.org/10./fcimb...