2-Fluoro-6-methoxyphenylboronic acid CAS 78495-63-3: A Guide to Its Properties, Suzuki–Miyaura Coupling Applications, and Sourcing

2-Fluoro-6-methoxyphenylboronic acid (CAS 78495-63-3) is an arylboronic acid used as a building block in carbon–carbon bond formation, especially Suzuki–Miyaura cross-coupling. Its boronic acid group provides the coupling handle, while the fluorine and methoxy substituents remain part of the aromatic structure and can influence the properties of the resulting molecule. The compound has the molecular formula C₇H₈BFO₃ and a molecular weight of approximately 169.95 g/mol. This guide covers its identity, practical reaction considerations, purchasing checks, and how to request a quote from Maison Chemical.

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Key Takeaways

• Identity: CAS 78495-63-3 identifies 2-fluoro-6-methoxyphenylboronic acid, an aromatic organoboron building block.
• Primary application: It can be evaluated as the boronic-acid coupling partner in Suzuki–Miyaura reactions with a suitable aryl or heteroaryl halide or related electrophile.
• Reaction planning: Catalyst, base, solvent, temperature, and substrate structure affect performance; optimize conditions for the specific coupling target.
• Procurement: Confirm identity, assay, impurity information, packaging, documentation, quantity, and delivery terms before placing an order.

Who This Guide Is For

This guide is intended for medicinal and process chemists, chemical procurement teams, and research organizations evaluating 2-fluoro-6-methoxyphenylboronic acid for synthesis. It is also relevant to buyers comparing suppliers or planning a transition from laboratory evaluation to a larger project requirement. Because reaction results and commercial terms depend on the specific application and batch, the information below is a decision-making framework rather than a guaranteed specification or validated procedure.

What Is 2-Fluoro-6-methoxyphenylboronic Acid?

Structure and chemical identity

The compound consists of a phenyl ring bearing a boronic acid group, a fluoro substituent, and a methoxy substituent. In the name, “2-fluoro” and “6-methoxy” describe the positions of those substituents relative to the ring carbon attached to the boronic acid group. The boronic acid functionality is the reactive site commonly used to form a new carbon–carbon bond in cross-coupling chemistry.

Its key identity data are summarized below. These values identify the substance, but they do not replace a supplier’s batch-specific certificate of analysis or other quality documents. Buyers should match the CAS number and chemical name on the quotation and shipping paperwork to the material requested.

Why the substituents matter

The fluorine and methoxy groups are structural features that may be retained in the product after coupling, depending on the reaction design. Their positions can affect molecular shape, electronic properties, and the behavior of a target compound, so this building block may be considered when a synthesis requires this particular substitution pattern. Those features alone do not establish a specific biological, performance, or commercial outcome; such conclusions require testing of the final molecule.

Suzuki–Miyaura Coupling Applications

Role in a coupling reaction

In a Suzuki–Miyaura reaction, an organoboron reagent couples with an appropriate organic electrophile in the presence of a transition-metal catalyst and a base. In this case, the aryl group attached to boron can serve as the fragment transferred to the electrophile, creating a new carbon–carbon bond. The method is commonly used to assemble biaryl and related aromatic structures, although suitability must be assessed for each substrate pair.

For example, a chemist may evaluate this reagent when a target structure requires a 2-fluoro-6-methoxyphenyl unit joined to another aromatic or heteroaromatic fragment. It may be considered in medicinal chemistry synthesis, discovery research, or the preparation of specialty organic intermediates. These are application contexts, not claims that a particular coupling yield or product has been demonstrated with every substrate.

Reaction factors to evaluate

Coupling performance depends on more than the identity of the boronic acid. The electrophile, catalyst system, base, solvent, water content, temperature, reaction time, and concentration can all affect conversion and selectivity. Boronic-acid stability and competing reactions may also matter, particularly when the reaction is extended or the substrate contains other reactive groups.

For an initial development screen, a chemist might use a representative 1.0 mmol reaction scale and compare boronic acid loadings around 1.0–1.5 equivalents. These are illustrative starting points for experimental planning, not validated conditions for CAS 78495-63-3. Catalyst loading, temperature, and reaction duration should be selected and adjusted based on the substrate, laboratory procedures, and analytical results.

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Material and Specification Overview

Buyers should distinguish chemical identity from commercial grade and batch acceptance criteria. A supplier’s listing may provide a stated assay or grade, but buyers should verify the current specification and available documentation for the lot being offered. Do not infer appearance, purity, storage life, or handling conditions from the compound name alone.

Before ordering, request the information relevant to your work, such as assay method and result, identification data, impurity limits where applicable, storage and handling guidance, and safety documentation. If a project requires a particular analytical method or tighter limits, make that requirement explicit before quotation. The supplier should confirm whether the requested specification can be met rather than leaving acceptance criteria implicit.

How to Select a Supplier

Procurement checklist

• Confirm identity: Check that the product name and CAS number, 78495-63-3, appear consistently across the quotation and documents.
• Review quality information: Ask which batch-specific documents are available, including a certificate of analysis and safety data sheet.
• Define your required quantity: State the quantity needed for evaluation or production planning, and ask about the available pack size and minimum order quantity.
• Clarify delivery: Request the quoted lead time, shipping terms, destination details, and any relevant handling requirements.
• Discuss project-specific needs: Identify analytical, packaging, or documentation requirements before order confirmation.

Price, MOQ, and lead time

Price and availability can vary with order quantity, specification, packaging, production or stock status, and shipping destination. Minimum order quantity and lead time should therefore be confirmed for the requested quantity and delivery location rather than assumed from a general product description. For a planned campaign, share the target quantity and expected schedule early so the supplier can assess the request and communicate applicable terms.

Where a new material is being evaluated, buyers may find it useful to request a smaller quantity if available and agree on acceptance criteria before scaling the purchase. The larger requirement should be discussed separately, particularly when a project depends on a repeat supply or a defined impurity profile. This approach helps procurement and chemistry teams evaluate technical fit and commercial feasibility together.

Common Sourcing and Application Mistakes

One avoidable mistake is relying on a name match without confirming the CAS number and substitution pattern. Closely related positional isomers can have different structures, so verify the requested 2-fluoro-6-methoxy arrangement against your intended route. Another mistake is treating a general assay value as proof that a material meets project-specific impurity or analytical requirements.

In reaction development, do not assume that a condition successful for another arylboronic acid will transfer directly to this compound. Begin with a controlled screen, monitor the reaction using suitable analytical methods, and record the exact reagent lot and conditions. If conversion or selectivity is unsatisfactory, review the electrophile, catalyst, base, solvent, and material quality before drawing conclusions about the reagent’s suitability.

Working with Maison Chemical

Maison Chemical can be contacted to discuss 2-fluoro-6-methoxyphenylboronic acid, CAS 78495-63-3, for a research, development, or procurement requirement. To help us respond accurately, include the quantity, destination country, intended timeline, and any required assay, documentation, packaging, or impurity criteria. We can then confirm the applicable product information, availability, quotation terms, and lead time for your request.

Conclusion and Next Steps

2-Fluoro-6-methoxyphenylboronic acid is an arylboronic acid building block with the formula C₇H₈BFO₃ and a molecular weight of approximately 169.95 g/mol. Its principal synthetic relevance is as a potential coupling partner in Suzuki–Miyaura chemistry when a target requires the corresponding substituted aryl fragment. Whether it is a good fit depends on the reaction substrate, optimized conditions, and the quality requirements of the project.

For a practical next step, confirm the required identity and specification, define the quantity and delivery schedule, and request batch-specific documentation before purchase. Contact Maison Chemical with those details to request current availability and a quotation. This provides a clear basis for evaluating both the chemical fit and the sourcing terms.

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